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Glucagon‐producingneuroendocrine tumour associated with hypoaminoacidaemia and skin lesions
Author(s) -
Allenspach K.,
Arnold P.,
Gnus T.,
Hauser B.,
Wolff C.,
Eberle C.,
Kommlnoth P.
Publication year - 2000
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2000.tb03232.x
Subject(s) - medicine , glucagon , immunohistochemistry , pathology , neuroendocrine tumour , somatostatin , islet , insulin
A nine‐year‐old neutered female crossbred Bernese mountain dog was diagnosed with superficial necrolytic dermatitis and a glucagon‐producing islet cell tumour. Laboratory findings included hyperglucagonaemia and hypoaminoacidaemia. The dog was euthanased because of progression of the disease, and necropsy revealed liver metastases of a neuroendocrine carcinoma with immunohistochemical expression of glucagon and somatostatin. This report represents a case of canine glucagonoma syndrome; the previously reported cases in dogs are also briefly described.