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Synthesis and Antitubercular Activity of Novel Amino Acid Derivatives
Author(s) -
Da Costa Cristiane F.,
Pinheiro Alessandra C.,
De Almeida Mauro V.,
Lourenço Maria C. S.,
De Souza Marcus V. N.
Publication year - 2012
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2011.01269.x
Subject(s) - cycloserine , chemistry , mycobacterium tuberculosis , minimum inhibitory concentration , in vitro , amino acid , antibacterial activity , combinatorial chemistry , stereochemistry , biochemistry , bacteria , antibiotics , tuberculosis , biology , medicine , pathology , genetics
In this work, 17 new N ‐acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 8b , 8e , 8f , 9a – d , and 10c exhibited an important minimum inhibitory concentration activity between 12.5 and 50 μg/mL, which can be compared with that of the tuberculostatic drug d ‐cycloserine (20 μg/mL).