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Cell Metabolism of Acyclovir Phosphonate Derivatives and Antiherpesvirus Activity of their Combinations with α 2 ‐Interferon
Author(s) -
Skoblov Yuri S.,
Karpenko Inna L.,
Jasko Maxim V.,
Kukhanova Marina K.,
Andronova Valery L.,
Galegov Georgy A.,
Sidorov Georgy V.,
Myasoedov Nicolai F.
Publication year - 2007
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2007.00517.x
Subject(s) - phosphonate , prodrug , vero cell , chemistry , interferon , metabolism , stereochemistry , biochemistry , combinatorial chemistry , virology , biology , in vitro
The combinational use of acyclovir (ACV) phosphonate esters and α 2 ‐interferon was shown to produce a synergistic effect on inhibition of HSV‐1 replication in Vero cell cultures. Unlike other acyclovir phosphonate derivatives studied earlier, ACV H‐phosphonate is not an ACV prodrug. On penetrating into the cells, it may be directly converted into ACV monophosphate escaping dephosphonylation–phosphorylation steps.
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