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Discovery of a novel HLA‐B*51 variant, B*51:112, in a Taiwanese bone marrow donor and identification of the plausible HLA haplotype in association with B*51:112
Author(s) -
Yang K. L.,
Lee S. K.,
Lin P. Y.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2012.01108.x
Subject(s) - haplotype , hla b , genetics , exon , sequence (biology) , biology , human leukocyte antigen , nucleotide , dna sequencing , dna , amino acid substitution , nucleic acid sequence , gene , allele , microbiology and biotechnology , mutation , antigen
Summary The sequence of B*51:112 is identical to the sequence of B*51:01:01 in exons 2, 3 and 4, except the nucleotides at positions 206 (C→A) and 213 (C→G). The nucleotide replacement caused one amino acid substitution at residue 45 (T→K). The plausible HLA‐A, ‐B and ‐DRB1 haplotype in association with B*51:112 may be deduced as HLA‐A*02‐B*51:112‐DRB1*12. The generation of B*51:112 was probably as the result of a DNA recombination event where B*40:01:01 acted as a sequence donor donating a segment of the DNA sequence to the recipient sequence B*51:01:01. The donor carrying B*51:112 was a Minna Taiwanese whose ancestor came to Taiwan from the southern region of China.