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HLA analysis of Sri Lankan Sinhalese predicts North Indian origin
Author(s) -
Malavige G. N.,
Rostron T.,
Seneviratne S. L.,
Fernando S.,
Sivayogan S.,
Wijewickrama A.,
Ogg G. S.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00698.x
Subject(s) - sri lanka , human leukocyte antigen , allele , hla a , population , typing , genetics , biology , medicine , south asia , ethnology , environmental health , gene , history , antigen
Summary The origin of the Sinhalese population of Sri Lanka is debated. We subtyped HLA‐A*02 in 101 Sinhalese and observed a preponderance of the rare allele HLA‐A*0211 which was similar to reported frequencies in northern India. Taken with low‐resolution typing for the remaining A, B, C, DR and DQ alleles, these data suggest a North Indian origin for the Sri Lankan Sinhalese.