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Alternations of phospholipid profile in placenta of streptozotocin‐induced diabetic rat
Author(s) -
Hasegawa Mina,
Tanaka Katsuhiro,
Komori Masayuki,
Takenaka Shigeo
Publication year - 2011
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.2011.00327.x
Subject(s) - streptozotocin , placenta , fetus , phospholipid , endocrinology , medicine , diabetes mellitus , pregnancy , chemistry , biology , biochemistry , membrane , genetics
Phospholipids have important roles in many biological processes, but their role in fetal malformation in pregnancy in diabetes is unclear. Metabolic fingerprinting of placental phospholipids in pregnant streptozotocin‐induced type 1 diabetic rats was performed using Fourier transform‐ion cyclotron resonance mass spectrometry. Some of the fetuses from the pregnant diabetic rats exhibited ventricular septal defects. Alterations of phospholipid compositions in the diabetic rat placenta were detected. We suggest that these changes in phospholipids in the diabetic placenta might be involved in development of fetal malformation in a type 1 diabetic pregnancy.