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ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes
Author(s) -
Dutta Ranjna C.,
Goldberg Erwin
Publication year - 2008
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2008.00587.x
Subject(s) - lactate dehydrogenase , in vivo , in vitro , antigen , pharmacology , biology , microbiology and biotechnology , biochemistry , chemistry , enzyme , immunology
Problem Is it possible to deliver therapeutic agents to testis through specific targeting? Method of study Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase‐C4 (LDH‐C 4 ), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo . Results It is observed that LDHC 4 ‐immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo . Conclusion Specific targeting through LDH‐C 4 appears to be a feasible strategy for delivering therapeutic as well as anti‐spermatogenic agents to testis.