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Leukemia Inhibitory Factor: An Important Regulator of Endometrial Function
Author(s) -
KonderaAnasz Zdzisława,
Sikora Justyna,
MielczarekPalacz Aleksandra
Publication year - 2004
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2004.00204.x
Subject(s) - leukemia inhibitory factor , endometrium , regulator , cytokine , luteal phase , infertility , menstrual cycle , endocrinology , medicine , leukemia inhibitory factor receptor , endometrial cancer , function (biology) , cancer research , hormone , biology , microbiology and biotechnology , interleukin 6 , cancer , pregnancy , biochemistry , genetics , gene
Problem: Leukemia inhibitory factor (LIF) is multifunctional cytokine that displays biological activities in different cells, including endometrial cells. The aim of this study is to describe implications of LIF on a physiological function of endometrium. Method of study: The role of LIF in the endometrial function is reviewed and summarized from the available literature. Results: LIF plays an important role in a physiological function of endometrium. In human endometrial LIF expression depends on cellular localizations, steroid hormones, menstrual stages and a local cytokine network. Stronger LIF expression exists in an endometrial epithelium during a luteal phase of the menstrual cycle, which coincides with the time of an implantation. The impairments of the endometrial LIF expression may play a significant role in the pathological processes involving implantation and the infertility. Conclusions: There is a substantial evidence that LIF is a potential regulator of the endometrial function and might be one of the factors that play a key role in human reproduction.