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Carcinogenesis in forestomach and changes in oral mucosa of rats induced by intragastric N‐methylnitrosourea
Author(s) -
REIBEL JESPER
Publication year - 1982
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/j.1600-0722.1982.tb00751.x
Subject(s) - carcinogenesis , oral administration , oral mucosa , epithelium , medicine , pathology , biology , endocrinology , cancer
– it is well known that oral administration oi N‐methylnitrosourea (NMU) induces carcinomas in the forestomach of experimental animals. As the rat forestomach is lined with an orthokeratinized squamous epithelium the purpose of the present study was to elucidate whether carcinogenesis in this localization following intragastric application of NMU was comparable to oral carcinogenesis in experimental animals and humans. Furthermore, the development of oral m u cos al lesions in the rats was studied. It is concluded that the morphologic changes seen during carcinogenesis in the forestomach do not seem to differ essentially from those seen during experimental and human oral carcinogenesis. Furthermore, the number of oral lesions found in the present study are higher than reported in other strains of rats following administration of NMU.