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NF‐κB subunit specificity in hemopoiesis
Author(s) -
Gerondakis Steve,
Banerjee Ashish,
Grigoriadis George,
Vasanthakumar Ajithkumar,
Gugasyan Raffi,
Sidwell Tom,
Grumont Raelene J
Publication year - 2012
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2011.01090.x
Subject(s) - haematopoiesis , biology , transcription factor , microbiology and biotechnology , myeloid , immunology , cellular differentiation , stem cell , genetics , gene
Summary: Although the diverse functions served by the nuclear factor‐κB (NF‐κB) pathway in virtually all cell types are typically employed to deal with stress responses, NF‐κB transcription factors also play key roles in the development of hemopoietic cells. This review focuses on how NF‐κB transcription factors control various aspects of thymic T‐cell and myeloid cell differentiation that include its roles in hemopoietic precursors, conventional αβ T cells, CD4 + regulatory T cells, natural killer T cells, γδ T cells, macrophages, and dendritic cells.