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Serum levels of cytokines after bone marrow transplantation: increased IL‐8 levels during severe veno‐occlusive disease of the liver
Author(s) -
Remberger M.,
Ringdén O.
Publication year - 1997
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1997.tb00985.x
Subject(s) - medicine , gastroenterology , complication , cytokine , bone marrow , hepatic veno occlusive disease , transplantation , liver transplantation , bilirubin , surgery , hematopoietic stem cell transplantation
We investigated the cytokine profile and peak levels of interleukin (IL) ‐6, IL‐8, IL‐10 and tumour necrosis factor (TNF) ‐α levels in 42 patients after allogeneic bone marrow transplantation (BMT). Eleven of them developed veno‐occlusive disease (VOD) of the liver. Fourteen patients had moderate‐to‐severe acute graft‐versus‐host disease (aGvHD), 10 isolated bacteraemia and 7 had no major complication. Those who developed severe VOD ( n = 6) showed a short, very high IL‐8 peak (median: 6632 pg/ml, range: 5546 – 10,000 vs. 280 pg/ml, 0 – 2042 in controls, p < 0.01) 1 – 4 d after diagnosis of the liver disease. Five of these patients had high peak levels of IL‐6. Five patients with mild VOD showed a lower increase in the cytokines tested. Bilirubin levels, at day of IL‐8 peak, did not differ statistically between mild and severe VOD. The highest levels of IL‐10 were found in those with aGvHD. IL‐8 levels were also increased, but not to the same extent as in patients with severe VOD ( p = 0.01 vs. VOD). In patients with bacteraemia, very high levels of IL‐6 were seen. In patients without major complications, the levels of cytokines were low. In conclusion, high levels of IL‐8 occurred in severe VOD of the liver, which may be of value to determine prognosis.