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Granulocyte Transfusions in Acute Leukaemia Regeneration of Granulopoiesis as Determining Factor of Survival
Author(s) -
Pflieger H.,
Arnold R.,
Bhaduri S.,
Dietrich M.,
Heimpel H.,
Kubane B.,
Rasche H.,
Wiesneth M.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01649.x
Subject(s) - granulopoiesis , medicine , granulocyte , surgery , blood transfusion , haematopoiesis , stem cell , genetics , biology
40 patients with acute leukaemia and severe granulocytopenia were treated with granulocyte transfusions for bacteriologically documented or clinically suspected septicaemia. The patients received an average of 5 transfusions each with 2.1 times 10 10 granulocytes per m 2 body surface area per day. 26 patients showed clinical benefit from transfusion therapy as documented by the course of blood cultures, local lesions and fever. Only patients with regeneration of granulopoiesis had definite benefit from granulocyte transfusions. All other patients died ultimately from septicaemia.