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Trisomy of 1q in Preleukaemia with Progression to Acute Leukaemia
Author(s) -
Najfeld Vesna,
Singer Jack V.,
James Melody C.,
Fialkow Philip J.
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb02491.x
Subject(s) - trisomy , chromosome , chromosomal abnormality , biology , acute myelomonocytic leukemia , long arm , ploidy , chromosome abnormality , abnormality , karyotype , aneuploidy , pathology , microbiology and biotechnology , bone marrow , genetics , immunology , medicine , gene , psychiatry
Marrow cells from an untreated man with preleukaemia were found to have trisomy for the long arm of chromosome 1 which was translocated to the end of the long arm of number 11, i.e., 46, XY, ‐11, +t (1:11) (q11 or q12; q25). The same abnormality was found in metaphases from 8 individual granulocytic colonies. With development of acute myelomonocytic leukaemia, in addition to the basic chromosome abnormality, trisomy of chromosome 8 and an extra chromosome number 19 with partial deletion were found. Fibroblasts grown from marrow biopsy material showed a normal diploid complement, 46, XY.