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Expression of MMP‐9, MMP‐10 and TNF‐α and lack of epithelial MMP‐1 and MMP‐26 characterize pyoderma gangrenosum
Author(s) -
Bister Ville,
Mäkitalo Laura,
Jeskanen Leila,
SaarialhoKere Ulpu
Publication year - 2007
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2007.00744.x
Subject(s) - matrix metalloproteinase , pyoderma gangrenosum , medicine , stromal cell , pathology , tumor necrosis factor alpha , wound healing , pathogenesis , necrosis , inflammation , inflammatory bowel disease , immunology , disease
Background: Pyoderma gangrenosum (PG) is a non‐infectious, autoimmune, chronic ulcer of the skin, often co‐existing with inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) have been implicated as mediators of tissue destruction in chronic cutaneous and intestinal wounds. Methods: Twenty‐four skin biopsies with clinically and histologically confirmed PG and acute wounds were immunostained for MMP‐1, ‐7, ‐8, ‐9, ‐10 and ‐26; tissue inhibitors of matrix metalloproteinase (TIMP)‐1 and ‐3 and tumor necrosis factor‐α (TNF‐α). Results: MMP‐1 was generally expressed by keratinocytes distal from the wound edge, whereas MMP‐10 was detected abundantly in the epithelium. MMP‐26 was positive in 42% at the migratory front. Abundant stromal expression was evident for MMP‐1, ‐9 and ‐10, TIMP‐1 and ‐3 and TNF‐α. In acute wounds, stromal MMP‐1, ‐9 and ‐10 and TNF‐α were sparse. Conclusions: Unlike in normally healing cutaneous wounds, MMP‐1 and ‐26 were detected bordering the wound in only a minority of PGs and their lack may thus retard epithelial repair. Particularly, MMP‐9 and ‐10 and TNF‐α would be suitable therapeutic targets as they may contribute to the degradation of provisional matrices needed for migration in healing wounds. The presence of MMP‐1, ‐9, ‐10 and ‐26 in both PG and IBD ulcers may suggest a similar pathogenesis for cutaneous and mucosal inflammation.