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Patch test concentrations (doses in mg/cm 2 ) for the 12 non‐mix fragrance substances regulated by European legislation
Author(s) -
Bruze Magnus,
Svedman Cecilia,
Andersen Klaus Ejner,
Bruynzeel Derk,
Goossens An,
Johansen Jeanne Duus,
Matura Mihaly,
Orton David,
Vigan Martine
Publication year - 2012
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2011.02037.x
Subject(s) - patch test , patch testing , contact dermatitis , chemistry , dermatology , medicine , toxicology , allergy , immunology , biology
Background. According to EU legislation, 26 fragrance substance allergens must be labelled on cosmetic products. For 12 of them, the optimal patch test concentration/dose has not been evaluated. Objectives. To establish the optimal patch test doses in mg/cm 2 for the 12 fragrance substances that are not included in fragrance mix I or II in the European baseline patch test series. Materials and Methods. Patch testing with the 12 fragrance substances was performed in a stepwise manner encompassing up to five rounds in at least 100 dermatitis patients for each round. Before patch testing, an individual maximum concentration/dose was determined for each fragrance substance. Results. The predetermined maximum patch test concentrations/doses could be tested for all 12 fragrance substances, with no observable adverse reactions being noted. Conclusions. For each fragrance substance investigated, it is recommended that half of the maximum patch test dose (mg/cm 2 ) be used for aimed and screening patch testing.