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Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis
Author(s) -
Šaňák D.,
Herzig R.,
Zapletalová J.,
Horák D.,
Král M.,
Školoudík D.,
Bártková A.,
Veverka T.,
Heřman M.,
Kaňovský P.
Publication year - 2011
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2010.01401.x
Subject(s) - medicine , thrombolysis , modified rankin scale , logistic regression , stroke (engine) , outcome (game theory) , multivariate analysis , acute stroke , cardiology , ischemic stroke , tissue plasminogen activator , ischemia , myocardial infarction , mechanical engineering , mathematics , mathematical economics , engineering
Šaňák D, Herzig R, Zapletalová J, Horák D, Král M, Školoudík D, Bártková A, Veverka T, Heřman M, Kaňovský P. Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis.
Acta Neurol Scand: 2011: 123: 339–344.
© 2010 John Wiley & Sons A/S. Objectives – Intravenous thrombolysis (IVT) is considered an effective treatment for acute ischemic stroke (IS). However, not all treated patients may achieve good outcome. The aim was to evaluate whether the initial NIHSS and DWI infarct volume could be the predictors for good outcome after IVT. Patients and Methods – The set of 125 patients with consecutive hemispheric IS (78 men; mean age 66.0 ± 12.1 years) treated with IVT within 3 h was analyzed. DWI volume was measured on admission. Good outcome was defined as a score 0‐2 in modified Rankin Scale. Results – Multivariate logistic regression analysis showed initial NIHSS as an independent predictor of good outcome ( P = 0.001). ROC curves showed baseline NIHSS ≤13.5 points and DWI volume ≤13.7 ml as cut‐offs related to good outcome. Conclusions – The initial NIHSS and DWI volume might be the predictors for good clinical outcome in acute stroke patients treated with IVT. The initial NIHSS score seems to be more accurate.