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Increased disability and MRI lesions after discontinuation of IFN‐ β ‐1a in secondary progressive MS
Author(s) -
Wu X.,
Dastidar P.,
Kuusisto H.,
Ukkonen M.,
Huhtala H.,
Elovaara I.
Publication year - 2005
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2005.00477.x
Subject(s) - discontinuation , multiple sclerosis , medicine , expanded disability status scale , magnetic resonance imaging , interferon beta 1b , interferon beta 1a , cerebrospinal fluid , central nervous system disease , gastroenterology , interferon beta , radiology , immunology
Objective – To examine neurological and magnetic resonance imaging (MRI) changes following discontinuation of interferon (IFN)‐ β ‐1a treatment in secondary progressive multiple sclerosis (SPMS). Methods – The study involved 21 SPMS patients who received subcutaneous (s.c.) IFN‐ β ‐1a 44 μ g three times weekly (t.i.w.) for 12 months and were thereafter followed up without treatment for a further 12 months. The number of relapses, disability on the Expanded Disability Status Scale (EDSS) and MRI were recorded at baseline, at 12 months of IFN‐ β ‐1a 44 μ g t.i.w. and 1 year after discontinuation of treatment. Results – During the 12‐month treatment EDSS score and volumes of brain T2‐ and T1‐weighted lesions remained without significant progression, but at 12 months after treatment discontinuation both EDSS score and the volumes of cerebral lesions increased significantly. Cerebrospinal fluid fraction increased significantly both during the treatment and during follow‐up. Conclusions – Discontinuation of IFN‐ β ‐1a 44 μ g t.i.w. in SPMS may be associated with an increase in neurological disability and brain lesions on MRI.