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Electrophysiologic Remodeling:
Author(s) -
NATTEL STANLEY
Publication year - 1999
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.1999.tb00214.x
Subject(s) - medicine , electrophysiologic study , cardiology , ion channel , rhythm , cardiac function curve , disease , neuroscience , heart failure , ventricular tachycardia , psychology , receptor
Ion Channels and Electrophysiologic Remodeling. Electrophysiologic remodeling refers to changes in cardiac electrophysiologic function caused by heart disease or arrhythmias. Recent work indicates that not only can ion channel abnormalities cause cardiac arrhythmias, but cardiac arrhythmias can cause ion channel abnormalities. Thus, ion channels do not only set the elcctrophysiologic milieu and cause arrhythmias in a static way when abnormal, but they also alter their properties in response to rhythm disorders, playing an active role in the evolution of disturbances in cardiac rhythm. This article briefly visits the concepts of electrophysiologic and ionic remodeling, and it presents some pertinent “hows,”“whys,” and “whats.” We are only beginning to appreciate the nature and importance of these fundamental mechanisms, which undoubtedly will provide major clues to the understanding and treatment of cardiac disease and arrhythmias over the next 5 to 10 years.