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Antibodies to Beta‐Adrenergic Receptors Disclosing Agonist‐Like Properties in Idiopathic Dilated Cardiomyopathy and Chagas’ Heart Disease
Author(s) -
ROSENBAUM MAURICIO B.,
CHIALE PABLO A.,
SCHEJTMAN DALIA,
LEVIN MARIANO,
ELIZARI MARCELO V.
Publication year - 1994
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.1994.tb01174.x
Subject(s) - medicine , dilated cardiomyopathy , chagas disease , cardiomyopathy , adrenergic receptor , heart disease , heart failure , cardiology , receptor , myocarditis , antibody , immunology
Antibodies to Beta‐Adrenergic Receptors. Recent studies confirm the existence of antibodies (Abs) to β adrenoceptors in patients with idiopathic dilated cardiomyopathy and Chagas’ heart disease. These Abs can be shown to exert both stimulatory and inhibitory effects, which may play a role in the development of the cardiac abnormalities known to occur in these diseases, including advanced heart failure. The hypothesis is advanced that Chagas’ heart disease and some forms of idiopathic dilated cardiomyopathy may represent, at least partially, a form of “adrenergic cardiomyopathy.”