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Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro
Author(s) -
Whyte LS,
Ford L,
Ridge SA,
Cameron GA,
Rogers MJ,
Ross RA
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01519.x
Subject(s) - osteoclast , endocannabinoid system , cannabinoid receptor , bone resorption , chemistry , cannabinoid , medicine , endocrinology , receptor , resorption , microbiology and biotechnology , bone remodeling , anandamide , pharmacology , biology , biochemistry , agonist
Both CB(1) and CB(2) cannabinoid receptors have been shown to play a role in bone metabolism. Crucially, previous studies have focussed on the effects of cannabinoid ligands in murine bone cells. This study aimed to investigate the effects of cannabinoids on human bone cells in vitro.