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Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor‐expressing cells: implications for its therapeutic action
Author(s) -
MarquesdaSilva C,
Chaves MM,
Castro NG,
CoutinhoSilva R,
Guimaraes MZP
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01254.x
Subject(s) - colchicine , receptor , microbiology and biotechnology , purinergic receptor , microtubule polymerization , biology , mechanism of action , hek 293 cells , chemistry , pharmacology , biochemistry , in vitro , microtubule , tubulin , genetics
The two longest C-termini of the purinergic P2X receptors occur in the P2X2 and P2X7 receptors and are thought to interact with multiple cytoplasmic proteins, among which are members of the cytoskeleton, including microtubules. In this work we asked whether disrupting the microtubule cytoskeleton might affect the functions of these receptors.