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How important are Rho GTPases in neurosecretion?
Author(s) -
Momboisse Fanny,
Houy Sébastien,
Ory Stéphane,
Calco Valérie,
Bader MarieFrance,
Gasman Stéphane
Publication year - 2011
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2011.07241.x
Subject(s) - gtpase , neurosecretion , microbiology and biotechnology , biology , ras superfamily , guanine nucleotide exchange factor , neuroscience , gtp' , biochemistry , enzyme
J. Neurochem. (2011) 117 , 623–631. Abstract Rho GTPases are small GTP binding proteins belonging to the Ras superfamily which act as molecular switches that regulate many cellular function including cell morphology, cell to cell interaction, cell migration and adhesion. In neuronal cells, Rho GTPases have been proposed to regulate neuronal development and synaptic plasticity. However, the role of Rho GTPases in neurosecretion is poorly documented. In this review, we discuss data that highlight the importance of Rho GTPases and their regulators into the control of neurotransmitter and hormone release in neurons and neuroendocrine cells, respectively.