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Evidence for Neuronal Localization of Histamine‐ N ‐Methyltransferase in Rat Brain
Author(s) -
Sperk Günther,
Hörtnagl Heide,
Reither Harald,
Hornykiewicz Oleh
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb00489.x
Subject(s) - histamine , neurochemical , histamine n methyltransferase , neurotransmitter , central nervous system , striatum , neuroscience , histamine h3 receptor , enzyme , chemistry , dopamine , biology , endocrinology , biochemistry , histamine h2 receptor , receptor , antagonist
There is evidence that histamine may be a neurotransmitter in mammalian brain. Histamine in neurons of the central nervous system is easily released and rapidly turned over. The cellular localization of histamine‐ N ‐methyltransferase, the proposed histamine‐inactivating enzyme, was investigated by measuring its activity in rat striatum after applying neurochemical or electrolytic lesions. The results indicate a major neuronal localization of the enzyme in this area.