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Changes in transferrin are related to changes in insulin resistance: the SLIM study
Author(s) -
Roumen C.,
Feskens E. J. M.,
Jansen E. H. J. M.,
Saris W. H. M.,
Blaak E. E.
Publication year - 2008
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2008.02589.x
Subject(s) - medicine , postprandial , ferritin , insulin resistance , transferrin , endocrinology , insulin , lipid metabolism , carbohydrate metabolism , impaired glucose tolerance
Aims To determine the effect of a lifestyle intervention on serum transferrin and ferritin levels and the relationship between changes in transferrin and ferritin and changes in glucose tolerance and insulin resistance. Methods Randomized controlled lifestyle intervention directed at a healthy diet and increased physical activity in subjects with impaired glucose tolerance. Results After 1 year, the change in ferritin levels in the intervention group as compared with the control group did not reach statistical significance ( P = 0.06). Transferrin change was independently related to the change in homeostasis model assessment of insulin resistance and ferritin change was related to the change in 2‐h free fatty acids. Conclusions Changes in insulin sensitivity and postprandial lipid metabolism are related to changes in iron metabolism.