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The 4G/4G PAI‐1 genotype is associated with elevated plasma PAI‐1 levels regardless of variables of the metabolic syndrome and smoking status. A population‐based study in Spanish population
Author(s) -
MartínezCalatrava M. J.,
MartínezLarrad M. T.,
Zabena C.,
GonzálezSánchez J. L.,
FernándezPérez C.,
SerranoRíos M.
Publication year - 2007
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2006.00584.x
Subject(s) - metabolic syndrome , waist , medicine , body mass index , population , endocrinology , genotype , demography , gastroenterology , obesity , biology , genetics , environmental health , sociology , gene
Reported data about the effect of the 4G/5G PAI‐1 polymorphism on plasma PAI‐1 levels are controversial. This study was designed to determine the relative effect of the 4G/5G PAI‐1 polymorphism on high plasma PAI‐1 levels after adjustment for metabolic syndrome – related variables, and to test if this effect is modified by the smoking status. Six hundred and thirty one unrelated subjects (292 men; 35–74 years), from a cross‐sectional population‐based epidemiological survey in the province of Segovia (Spain) were studied. The higher frequency of high PAI‐1 levels was found in 4G/4G subjects (5G/5G 19.4%, 4G/5G 21.6%, 4G/4G 33.7%, p = 0.003). A multiple regression model, adjusted for gender, age, BMI, waist circumference, triglycerides, HDL‐cholesterol, HOMA IR and leptin, showed this adjOR: 4G/4G vs 5G/5G: 2.22, p = 0.008. When smoking status – 4G/5G PAI‐1 interaction was included as an independent variable these results were not modified. Our results indicate that the 4G/4G PAI‐1 genotype might be strongly associated with high PAI‐1 levels regardless of metabolic syndrome‐related variables and smoking status.