Premium
Repeat episodes of severe muscle rigidity in a child receiving sevoflurane
Author(s) -
COHEN IRA TODD,
KAPLAN RICHARD
Publication year - 2006
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.2006.01920.x
Subject(s) - sevoflurane , malignant hyperthermia , medicine , dantrolene , muscle rigidity , creatine kinase , anesthesia , rhabdomyolysis , calcium
Summary We report on a patient who developed two episodes of severe muscle rigidity, increased endtidal CO 2 and increased creatine phosphate kinase associated with sevoflurane anesthesia. Dysrhythmias and hyperthermia were not observed and dantrolene was not administered. Genetic testing for the 17 known mutations associated with malignant hyperthermia (MH) was negative. Although we cannot rule out MH or other neuromuscular diseases we suggest that this rare event may be a direct effect of sevoflurane.