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Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis
Author(s) -
Kalu Emmanuel,
Sumar Nazira,
Giannopoulos Theodoros,
Patel Pinika,
Croucher Carolyn,
Sherriff Elizabeth,
Bansal Amolak
Publication year - 2007
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2007.00569.x
Subject(s) - peritoneal fluid , medicine , endometriosis , cytokine , vascular endothelial growth factor , infertility , tumor necrosis factor alpha , pathogenesis , interleukin , interleukin 6 , endocrinology , vegf receptors , pregnancy , biology , genetics
Objective: To study the serum and peritoneal fluid cytokine profiles in infertile women with minimal/mild active endometriosis. Methods: Fifty‐seven consecutive infertile women undergoing laparoscopy for unexplained infertility had peritoneal fluid and serum samples obtained at the time of laparoscopy. The levels of interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), interleukin‐1 beta (IL‐1 β), vascular endothelial growth factor (VEGF), tumor necrosis factor‐alpha (TNF‐α), monocyte chemotatic protein‐1 (MCP‐1), RANTES, platelet derived growth factor (PDGF), soluble Fas (sFas), and soluble Fas Ligand (sFasL) in peritoneal fluid and serum were measured to compare the concentration in both biological fluids, in women who have minimal/mild red endometriosis using women with no endometriosis as controls. Results: Peritoneal fluid levels of MCP‐1, IL‐8 and IL‐6 were significantly higher in the endometriosis group ( P < 0.012, P = 0.003, and P = 0.015, respectively). There was no significant difference in the peritoneal fluid levels of IL‐1 β, TNF‐α, RANTES, VEGF, PDGF, sFas and sFasL in the two groups. Although serum levels of IL‐8 were higher in women with endometriosis, the difference was not significant ( P = 0.07). Serum levels of PDGF, IL‐6, RANTES, IL‐1 β, TNF‐α, and sFas, were not significantly different in the two groups. Conclusion: The elevated levels of MCP‐1, IL‐6, and IL‐8 in peritoneal fluid but not serum may indicate the importance of local macrophage activating factors in the pathogenesis of endometriosis.