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Profound lymphopenia and bacteraemia
Author(s) -
Hawkins C. A.,
Collig P.,
Adams D. N.,
Bowden F. J.,
Cook M. C.
Publication year - 2006
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2006.01076.x
Subject(s) - medicine , bacteremia , comorbidity , cohort , intensive care medicine , sepsis , leukopenia , antibiotics , immunology , chemotherapy , microbiology and biotechnology , biology
Bacteraemia often carries a poor prognosis despite prompt antibiotic therapy and is associated with late morbidity and mortality that is difficult to explain. Here, we describe perisistent B‐ and T‐ cell lymphopenia in a cohort of patients with Gram‐positive and Gram‐negative bacteraemia. This suggests previously unrecognized mechanisms of subversion of immunity by pathogens and might explain the comorbidity of blood stream infection with bacteria.