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Early hepatocellular carcinoma macroscopically resembling adenomatous hyperplasia: Pathological resemblance to carcinoma‐in‐situ
Author(s) -
Wakasa Kenichi,
Haba Tomoko,
Hamada Tomomi,
Sasaki Masaomi,
Sakurai Masaml
Publication year - 1997
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1997.tb04434.x
Subject(s) - pathology , hepatocellular carcinoma , atypical adenomatous hyperplasia , carcinoma , medicine , cd68 , pathological , parenchyma , hyperplasia , carcinoma in situ , immunohistochemistry , adenocarcinoma , cancer
The pathological features of 11 nodules of early hepatocellular carcinoma (EHCC) were studled. Their macroscopic features resembled those of adenomatous hyperplasia and differed from those of advanced hepatocellular carcinomas (AHCC). The EHCC extended along the hepatic lobular structure and lacked expansive growth. The endothelial cells in the dnusoids of EHCC did not react to Ulex europeeus aggiutinin 1 (UEA1) like adenomatous hyperplasla or other liver parenchyma, whereas the endothelial celis in the AHCC did react to UEA1. immunohistochemically, CD68‐positlve Kupffer cells were noted in the alnusolds of EHCC, whereas in the AHCC Kupfter cails were not seen. Tumor emboli in the portal vein and intrahepatic metastases were not Identified In EHCC. which seemed to be carcinoma‐in‐situ or a microinvasive stage of hepatocareinogenesis.