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How do people with chronic kidney disease value cancer‐related quality of life?
Author(s) -
WONG GERMAINE,
HOWARD KIRSTEN,
CHAPMAN JEREMY,
POLLOCK CAROL,
CHADBAN STEVEN,
SALKELD GLENN,
TONG ALLISON,
WILLIAMS NARELLE,
WEBSTER ANGELA,
CRAIG JONATHAN C
Publication year - 2012
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/j.1440-1797.2011.01531.x
Subject(s) - medicine , kidney disease , quality of life (healthcare) , colorectal cancer , dialysis , time trade off , cancer , stage (stratigraphy) , disease , gerontology , paleontology , nursing , biology
Objectives: To estimate the utility‐based quality of life (QOL) of people with chronic kidney disease (CKD) and to estimate the QOL associated with two hypothetical colorectal cancer health states. Methods: A cross‐sectional study was conducted in people with CKD (stages 3–5, transplant recipients and those on dialysis) from three centres in Sydney, Australia. We measured participants' own QOL and that of two hypothetical colorectal cancer health states using a rating scale, and a utility‐based QOL measure, the time trade‐off, with extremes of 0 (death) and 1 (full health). Results: Recipients of kidney transplants ( n = 79) had the highest mean QOL weights of 0.79 (standard deviation (SD) = 0.34) compared with participants with CKD 3–5 ( n = 53) with mean QOL weights of 0.70 (SD = 0.39), and those on dialysis ( n = 89), who had the lowest mean QOL weights of 0.62 (SD = 0.41) ( P = 0.02). Having early and advanced stage colorectal cancers were valued at mean QOL weights of 0.44 (SD = 0.41) and 0.12 (SD = 0.25) among people with moderate stage CKD; 0.45 (SD = 0.39) and 0.11 (SD = 0.24) among dialysis patients; 0.62 (SD = 0.36) and 0.18 (SD = 0.29) among kidney transplant recipients. Conclusions: People with CKD have poor QOL. Having coexistent illnesses such as cancer further reduces the overall well‐being of individuals with kidney disease. In addition to the development of effective screening and treatment programs to improve cancer outcomes in people with CKD, our study also highlights the need for effective interventions to improve the QOL in people with CKD, particularly those with major comorbidities like cancer.