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Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma according to C hild– P ugh classification
Author(s) -
Miyaki Daisuke,
Aikata Hiroshi,
Honda Yohji,
Naeshiro Noriaki,
Nakahara Takashi,
Tanaka Mio,
Nagaoki Yuko,
Kawaoka Tomokazu,
Takaki Shintaro,
Waki Koji,
Hiramatsu Akira,
Takahashi Shoichi,
Ishikawa Masaki,
Kakizawa Hideaki,
Awai Kazuo,
Chayama Kazuaki
Publication year - 2012
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2012.07276.x
Subject(s) - medicine , hepatocellular carcinoma , gastroenterology , complete response , chemotherapy , survival rate , overall survival
Background and Aim We compared the treatment response, survival, and safety to hepatic arterial infusion chemotherapy ( HAIC ) in patients with advanced hepatocellular carcinoma ( HCC ) according to C hild– P ugh ( CP ) score. Methods The study subjects were 249 patients with advanced HCC and CP class A and B who had been treated with HAIC . Patients were grouped according to CP score (5/6, 7 and 8/9) and their tumor response, tolerance, and survival were assessed. Results The median survival time ( MST ) was 8.2, 9.7, 6.3, and 3.9 months for the whole group, patients with CP 5/6, 7 and 8/9, respectively ( P < 0.0001). Complete response ( CR ) and partial response ( PR ) were seen in 11 and 57 patients, respectively, with an overall response rate of 27.3%. The response rate was higher in patients with CP score 5/6 and 7, than CP 8/9 (30.5%, 28.2%, 13.8%). The dropout rate was significantly higher in patients with CP score 8/9 than the other two (8.0%, 12.8%, 33.3%, respectively). The survival rate was significantly better in patients who achieved CR / PR than the others with CP score 5/6, 7. CP score 8/9 was an independent negative factor for response and survival. Conclusion Advanced HCC patients with CP score of 5/6 and 7 showed a better response to HAIC and better prognosis than those with CP score 8/9.