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The serological and genetic basis of the cis ‐AB blood group in Korea
Author(s) -
Cho D.,
Kim S.H.,
Jeon M.J.,
Choi K.L.,
Kee S.J.,
Shin M.G.,
Shin J.H.,
Suh S.P.,
Yazer M. H.,
Ryang D.W.
Publication year - 2004
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.2004.00528.x
Subject(s) - serology , genotype , allele , restriction fragment length polymorphism , biology , polymerase chain reaction , microbiology and biotechnology , genetics , polymorphism (computer science) , phenotype , group b , group a , gene , medicine , antibody
Background and Objectives The cis ‐AB blood group is rare, although relatively common amongst Koreans. The serological characteristics and genetic basis of Korean cis ‐AB blood donors were investigated. Materials and Methods Polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP), designed to detect the cis‐AB01 allele, was performed on 194 AB samples which demonstrated weak or unusual expression of either or both of the A or B antigens. Results and Conclusions Sixty cis‐AB01 donors were identified. cis‐AB01/O01 or O02 were the most common genotypes (36/60) detected only in A 2 B 3 donors, and cis‐AB01/B101 (nine of 60) was the least common genotype identified only in A 2 B donors. Surprisingly cis‐AB01/A102 (15/60) was identified in a variety of phenotypes (A 1 B 3 , A 1 B x or el, A int B 3 ).