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Oxygen extraction in pigs subjected to low‐dose infusion of endotoxin after major abdominal surgery
Author(s) -
Porta F.,
Takala J.,
Kolarova A.,
Ma Y.,
Redaelli C. A.,
Brander L.,
Bracht H.,
Jakob S. M.
Publication year - 2005
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2005.00683.x
Subject(s) - medicine , oxygen , saline , sepsis , anesthesia , hemodynamics , metabolism , chemistry , organic chemistry
Background: Sepsis may impair O 2 extraction due to blood flow redistribution or decreased utilization of the available oxygen. Methods: We assessed the effect of endotoxemia on systemic and regional O 2 extraction and lactate handling in pigs, randomized to receive either endotoxin (0.4 µg kg −1 h −1 ; n = 10) or saline infusion (controls; n = 9) for 12 h. Results: High baseline regional and systemic O 2 extraction in the endotoxin group (median 56%, range 45–77%) and in the controls (67%, 49–72%) was maintained until the end of the experiment (endotoxin group: 60%, 50–71%; controls: 60%, 50–74%) despite hypotension and a decrease in stroke volume in endotoxic animals. Hepatic lactate exchange decreased during endotoxemia from 14 µmol kg −1 min −1 (range 10–28 µmol kg −1 min −1 ) to 10 (range 3–15) µmol kg −1 min −1 ; P < 0.01), but remained stable in the controls, with 13 µmol min −1 (4–18 µmol min −1 ) at baseline and 7 µmol min −1 (3–17 µmol min −1 ) after 12 h of saline infusion. Conclusions: The high and sustained oxygen consumption and oxygen extraction in this endotoxemic model speak against any major impairment of hepatosplanchnic or systemic oxygen extraction and oxidative metabolism. The reduced hepatic lactate exchange despite an unchanged hepatic lactate influx suggests altered metabolic activities independent of oxygen consumption.