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Chronic hepatitis E in hematopoietic stem cell transplant patients in a low‐endemic country?
Author(s) -
Koenecke C.,
Pischke S.,
Heim A.,
Raggub L.,
Bremer B.,
Raupach R.,
Buchholz S.,
Schulz T.,
Manns M.P.,
Ganser A.,
Wedemeyer H.
Publication year - 2012
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2011.00702.x
Subject(s) - medicine , hematopoietic stem cell transplantation , hepatitis e , hepatitis e virus , cohort , hepatitis , chronic hepatitis , immunology , transplantation , liver transplantation , virology , virus , genotype , biology , gene , biochemistry
Abstract Cases of chronic hepatitis E have been described in patients after kidney and liver transplantation. In addition, hepatitis E virus ( HEV ) reactivation was reported after hematopoietic stem cell transplantation ( HSCT ). We here evaluated if HEV infection might explain elevated liver enzymes in a well selected cohort of allogeneic HSCT patients with biochemical evidence of hepatitis ( n  = 52). Of note, none of the subjects tested positive for HEV RNA , including 2 HSCT patients who had been infected with HEV already before transplantation. Thus, both chronic courses of HEV infections and HEV reactivations seem to be rather rare events in HSCT patients in a non‐endemic country.

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