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Reviews on mysterious vascular endothelial cells in renal allografts
Author(s) -
Yamaguchi Yutaka
Publication year - 2012
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2012.01675.x
Subject(s) - medicine , pathogenesis , antigen , immunology , abo blood group system , antibody , human leukocyte antigen , endothelium , transplantation , peritubular capillaries , isoantibodies , histocompatibility
Endothelial cells (ECs) are involved in allograft rejection and are prime targets, but also key players. HLA antigens are the most prominent targets of alloantibodies in transplantation. Alloantibodies against other antigens such as ABO blood group antigens and non‐HLA antigens could also be demonstrated. Alloantibodies undoubtedly cause allograft rejection. Activation of ECs by anti‐EC antibodies and direct antibody‐ or complement mediated EC damage may be suggested. However, the mechanisms underlying acute antibody‐mediated rejection (AAMR) and chronic rejection (CR) remain unclear. In this review, the relationship between vascular endothelium and rejection is discussed mainly from our reports, and the mechanism and pathogenesis of CR are discussed.