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Statins in dermatology
Author(s) -
Jowkar Farideh,
Namazi Mohammad Reza
Publication year - 2010
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2010.04579.x
Subject(s) - medicine , rhinophyma , rosacea , acne , psoriasis , dermatology , vitiligo , isotretinoin , niacin , atorvastatin , pharmacology
Statins are competitive inhibitors of 3‐hydroxy‐3‐methylyglutaryl‐coenzyme A reductase and reduce low‐density lipoprotein‐C levels. Statins are well‐tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Statins possess anti‐inflammatory, immunomodulatory, antioxidant, metabolic, and possible anticancer effects. Statins are reported to be effective against psoriasis, dermatitis, graft‐versus‐host disease, uremic pruritus, vitiligo, and hirsutism. Topical forms of statins are employed in the treatment of acne, seborrhea, rosacea, and rhinophyma. Animal studies show the beneficial effect of statins against contact dermatitis and wound healing. They have promising anti‐HIV effects as well. This article succinctly reviews the various cellular and molecular effects of statins, their applications in cutaneous medicine and their side effects.