Premium
Enrichment of invariant natural killer T cells in the bone marrow of visceral leishmaniasis patients
Author(s) -
RAI A. K.,
THAKUR C. P.,
SETH T.,
MITRA D. K.
Publication year - 2011
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.2011.01328.x
Subject(s) - visceral leishmaniasis , immunology , leishmania donovani , bone marrow , biology , leishmaniasis , natural killer t cell , antigen , cd1d , disease , leishmania , pathology , medicine , parasite hosting , world wide web , computer science , cd8
Summary Lipid antigens of Leishmania donovani like lipophosphoglycans are shown as a potent ligand for the activation of invariant natural killer T (iNKT) cells. It is reported that activation of iNKT cells augments the disease pathology in experimental visceral leishmaniasis (VL). In this study, we demonstrate the enrichment of iNKT cells in the bone marrow, one of the disease sites among patients with VL.