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An optical differential scanning calorimeter cryomicroscope
Author(s) -
YUAN S.,
DILLER K. R.
Publication year - 2005
Publication title -
journal of microscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0022-2720
DOI - 10.1111/j.1365-2818.2005.01474.x
Subject(s) - differential scanning calorimetry , materials science , calorimeter (particle physics) , dodecane , thermal , optics , chemistry , physics , thermodynamics , detector , organic chemistry
Summary An optical‐DSC system was designed, built, tested, calibrated and verified to incorporate into a single device the capability for simultaneous optical cryomicroscopy and differential scanning calorimetry (DSC). This instrument can be used to obtain both visual and thermal data for an individual specimen subjected to a defined freezing and thawing protocol with very little compromise in quality or range of data available in comparison with dedicated single instruments. Temperature and caloric calibrations were performed based on phase transition states in water, n‐dodecane and n‐decane. The instrument has proven effective for process analysis in living cells and in foodstuffs.