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Classical juvenile pityriasis rubra pilaris in a patient with Down syndrome
Author(s) -
Terasaki K.,
Kanekura T.,
Saruwatari H.,
Kanzaki T.
Publication year - 2004
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2004.01449.x
Subject(s) - pityriasis rubra pilaris , juvenile , medicine , dermatology , biology , psoriasis , genetics
Summary We report a case of classical juvenile pityriasis rubra pilaris (CJPRP) in a 15‐year‐old boy with Down syndrome. The rash was extensive, severe, accompanied by intense itching and responded to low‐dose etretinate. Xerosis and cheilitis were also present, suggesting that keratinization defects associated with Down syndrome may be involved in the pathogenesis of CJPRP. PRP is a rare dermatological disorder and to the best of our knowledge, this is the first reported case of CJPRP in a patient with Down syndrome.