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Complement activation in psoriasis
Author(s) -
ROSENBERG E.W.,
NOAH P.W.,
WYATT R.J.,
JONES R.M.,
KOLB W.P.
Publication year - 1990
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1990.tb02011.x
Subject(s) - psoriasis , complement (music) , complement system , medicine , dermatology , immunology , antibody , biology , genetics , complementation , gene , phenotype
Summary Plasma from 16 patients with psoriasis and 12 healthy control subjects were measured for iC3b, C4d, and Bb fragments generated by complement activation. Plasma concentrations for iC3b, C4d, and Bb fragments were found to be significantly increased in the patients with psoriasis. The highest concentrations of these complement activation fragments were seen in patients with erythrodermic pustular psoriasis, psoriatic arthritis, and Reiter's syndrome. The serum concentrations of complement components and regulatory proteins were normal or elevated in almost all samples.