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Integrated profiling of diffuse large B‐cell lymphoma with 7q gain
Author(s) -
Chigrinova Ekaterina,
Mian Michael,
Shen Yulei,
Greiner Timothy C.,
Chan Wing C.,
Vose Julie M.,
Inghirami Giorgio,
Chiappella Annalisa,
Baldini Luca,
Ponzoni Maurilio,
Ferreri Andrés J. M.,
Franceschetti Silvia,
Gaidano Gianluca,
Tucci Alessandra,
Facchetti Fabio,
Lazure Thierry,
Lambotte Olivier,
MontesMoreno Santiago,
Piris Miguel A.,
Zucca Emanuele,
Kwee Ivo,
Bertoni Francesco
Publication year - 2011
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2011.08628.x
Subject(s) - diffuse large b cell lymphoma , gene expression profiling , lymphoma , biology , microrna , bone marrow , cancer research , oncology , medicine , gene , gene expression , genetics , immunology
Summary To characterize diffuse large B‐cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R‐CHOP. Lesions were inversely associated with bone marrow involvement and number of extra‐nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96 , MIR182 , MIR589 , MIR25 were shown significantly up‐regulated in 7q+ DLBCL by real‐time PCR .