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Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia
Author(s) -
Eggleston B.,
Patience M.,
Edwards S.,
Adamkiewicz T.,
Buchanan G. R.,
Davies S. C.,
Dickerhoff R.,
Donfield S.,
Feig S. A.,
Giller R. H.,
Haight A.,
Horan J.,
Hsu L. L.,
Kamani N.,
Lane P.,
Levine J. E.,
Margolis D.,
Moore T. B.,
OheneFrempong K.,
ReddingLallinger R.,
Roberts I. A. G.,
Rogers Z. R.,
Sanders J. E.,
Scott J. P.,
Sleight B.,
Thompson A. A.,
Sullivan K. M.,
Walters M. C.
Publication year - 2007
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06486.x
Subject(s) - medicine , transplantation , haematopoiesis , anemia , pediatrics , hematopoietic cell , hematology , stem cell , biology , genetics
Summary Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short‐ and long‐term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.