A lesson to be learned from Karl Marx: smoking triggers hidradenitis suppurativa

1 Rugg EL, Leigh IM. The keratins and their disorders. Am J Med Genet C Semin Med Genet 2004; 131C:4–11. 2 Bernier V, Lagace M, Bichet DG et al. Pharmacological chaperones: potential treatment for conformational diseases. Trends Endocrinol Metab 2004; 15:222–8. 3 Morley SM, Dundas SR, James JL et al. Temperature sensitivity of the keratin cytoskeleton and delayed spreading of keratinocyte lines derived from EBS patients. J Cell Sci 1995; 108:3463–71. 4 Daehn IS, Varelias A, Rayner TE. Sodium butyrate induced keratinocyte apoptosis. Apoptosis 2006; 11:1379–90. 5 Smith FJ, Corden LD, Rugg EL et al. Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex. J Invest Dermatol 1997; 108:220–3. 6 de Nadal E, Alepuz PM, Posas F. Dealing with osmostress through MAP kinase activation. EMBO Rep 2002; 3:735–40. 7 Rosette C, Karin M. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 1996; 274:1194–7. 8 Yancey PH. Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. J Exp Biol 2005; 208:2819–30. 9 D’Alessandro M, Russell D, Morley SM et al. Keratin mutations of epidermolysis bullosa simplex alter the kinetics of stress response to osmotic shock. J Cell Sci 2002; 115:4341–51.