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The role of stress in ageing: research on the nematode, Caenorhabditis elegans
Author(s) -
Ishii N.
Publication year - 2005
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2005.06963.x
Subject(s) - caenorhabditis elegans , biology , caenorhabditis , nematode , oxidative stress , model organism , mutant , ageing , longevity , mitochondrion , genetics , life span , insulin , insulin receptor , mutation , microbiology and biotechnology , evolutionary biology , computational biology , neuroscience , gene , ecology , endocrinology , insulin resistance
Summary The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging and the roles of stress. In this review we focus on the genetics of select long‐lived and short‐lived mutants of C. elegans that have proven useful in revealing the relationships that exist between oxidative stress and life span. The former are known to be controlled by an insulin/insulin‐like signaling pathway, while the latter are affected by mitochondrial functions.