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The selective culture of keratinocytes using a cytotoxic antifibroblast monoclonal antibody
Author(s) -
GUSTERSON B.A.,
EDWARDS P.A.W.,
FOSTER C.S.,
NEVILLE A.M.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb01285.x
Subject(s) - monoclonal antibody , cytotoxicity , cytotoxic t cell , antibody , monoclonal , cell culture , immunology , keratinocyte , microbiology and biotechnology , chemistry , biology , cancer research , in vitro , biochemistry , genetics
SUMMARY A technique is described for the selective killing of fibroblasts in primary cultures and subcultures of human keratinocytes using a monoclonal antibody raised against human fibroblasts. The antibody kills fibroblasts by complement mediated cytotoxicity but is not toxic to keratinocytes.