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Complement and immunoglobulin deposits in the skin of patients with atopic dermatitis
Author(s) -
RING JOHANNES,
SENTER THOMAS,
CORNELL ROGER C.,
ARROYAVE CARLOS M.,
TAN ENG M.
Publication year - 1978
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1978.tb02016.x
Subject(s) - atopic dermatitis , complement (music) , dermatology , medicine , immunoglobulin e , antibody , immunology , immunoglobulin g , immunoglobulin a , biology , phenotype , genetics , complementation , gene
SUMMARY The immunofluorescent patterns of uninvolved and involved skin biopsies from eight patients with atopic dermatitis were studied, using direct immunofluorescence techniques to identify deposits of the immunoglobulins G, A and M as well as the complement factors C Iq , C 3 , C 4 , C 5 , factor B and properdin. Immunoglobulin deposits (mainly IgG) were found in five patients, complement deposits in three patients in the basement membrane zone. In three patients the immunofluorescence was positive for C 3 , in two patients for C Iq , C 4 and C 5 . Regarding the factors of the alternative pathway of the complement system, two patients showed deposits of properdin, one of factor B. The changes were not confined to the eczematous lesions, but were found in uninvolved skin too. The most prominent changes were observed in patients with severe disease.