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Debrisoquine oxidation phenotype and susceptibility to lung cancer.
Author(s) -
Speirs CJ,
Murray S,
Davies DS,
Mabadeje Biola AF,
Boobis AR
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03608.x
Subject(s) - debrisoquine , phenotype , lung cancer , medicine , cancer , bioinformatics , oncology , cancer research , biology , genetics , cyp2d6 , cytochrome p450 , gene , metabolism
1. It has been suggested that poor metabolisers of debrisoquine are at reduced risk of developing lung cancer from smoking cigarettes. This has been investigated in 82 patients with established cancer of the lung. 2. The frequency of poor metaboliser subjects was not different from that in the normal population. 3. There was no tendency for subjects with lung cancer to metabolise debrisoquine more rapidly than non‐cancer subjects. 4. It is concluded that debrisoquine metabolic phenotype is not a good predictor of risk of developing lung cancer in the population at large.