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The pre‐emptive analgesic effect of a cyclooxygenase‐2 inhibitor in a rat model of acute postoperative pain
Author(s) -
Chen J. J.,
Hung K. C.,
Lu K.,
Yu S. W.,
Chang C. C.,
Liu C. C.,
Spielberger J.,
Ku P. Y.,
Tan P. H.
Publication year - 2012
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2012.07246.x
Subject(s) - medicine , cyclooxygenase , analgesic , anesthesia , hyperalgesia , allodynia , postoperative pain , cox 2 inhibitor , surgery , pharmacology , nociception , receptor , enzyme , biochemistry , chemistry
Summary We examined the pre‐emptive analgesic effect of a cyclooxygenase (COX)‐2 inhibitor in a rat surgical pain model and characterised the changes in cutaneous COX‐2 around a surgical site. Thermal hyperalgesia and mechanical allodynia were tested in the rats for three days after incision and skin tissues were collected for analysis of COX‐2. There was decreased expression of cutaneous COX‐2 one day after surgical incision. Pre‐incision injection of the COX‐2 inhibitor significantly inhibited expression of COX‐2 and also reduced thermal hyperalgesia (but not mechanical allodynia) compared with the post‐incision COX‐2‐inhibitor injection group, one day after incision.