Open AccessAntitumor effects of α‐bisabolol against pancreatic cancer
Author(s) -
Seki Takashi,
Kokuryo Toshio,
Yokoyama Yukihiro,
Suzuki Hisanori,
Itatsu Keita,
Nakagawa Akifumi,
Mizutani Tetsushi,
Miyake Takashi,
Uno Masanori,
Yamauchi Kohei,
Nagino Masato
Publication year - 2011
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/j.1349-7006.2011.02082.x
Subject(s) - pancreatic cancer , apoptosis , cancer research , cell growth , cell culture , cancer , protein kinase b , pharmacology , medicine , pancreas , endocrinology , biology , biochemistry , genetics
In the present study, we investigated whether α‐bisabolol, a sesquiterpene alcohol present in essential oils derived from a variety of plants, has antitumor effects against pancreatic cancer. α‐Bisabolol induced a decrease in cell proliferation and viability in pancreatic cancer cell lines (KLM1, KP4, Panc1, MIA Paca2), but not in pancreatic epithelial cells (ACBRI515). α‐Bisabolol treatment induced apoptosis and suppressed Akt activation in pancreatic cancer cell lines. Furthermore, α‐bisabolol treatment induced the overexpression of early growth response‐1 (EGR1), whereas EGR1 siRNA decreased the α‐bisabolol‐induced cell death of KLM1 cells. Tumor growth in both subcutaneous and peritoneal xenograft nude mouse models was significantly inhibited by intragastric administration of 1000 mg/kg of α‐bisabolol, once a week for three weeks. The results indicate that α‐bisabolol could be a novel therapeutic option for the treatment of pancreatic cancer. ( Cancer Sci 2011; 102: 2199–2205)