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Granulomas induced by subcutaneous injection of leuprorelin acetate
Author(s) -
SAKAMOTO Ryoko,
HIGASHI Yuko,
MERA Kentaro,
KANEKURA Takuro,
KANZAKI Tamotsu
Publication year - 2006
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2006.00008.x
Subject(s) - leuprorelin , medicine , prostate cancer , agonist , hormone , luteinizing hormone , cancer , receptor , gonadotropin releasing hormone
Leuprorelin acetate, a chemotherapeutic agent used to treat prostate cancer, is a synthetic luteinizing hormone‐releasing hormone (LHRH) agonist. We report a 75‐year‐old man who presented with several large subcutaneous nodules at the site of leuprorelin acetate injections for his prostatic cancer. A biopsy of the nodules disclosed epithelioid granulomatous inflammation and resulted in a diagnosis of drug‐induced granulomatous reaction to leuprorelin acetate.